Your Pet’s Liver Works Around the Clock — Give It the Support It Deserves

The liver is one of the hardest-working organs in your pet’s body. It detoxifies the blood, metabolises nutrients, produces bile for digestion, synthesises proteins, regulates hormones, and processes every medication and toxin the body encounters. When the liver is compromised — by disease, chronic medication use, toxin exposure, or the accumulated wear of ageing — the impact extends to virtually every other system in the body.

HepNSure by Natural Remedies Pvt. Ltd. is an advanced, science-backed hepatoprotective supplement specifically formulated for dogs and cats with liver health concerns. Its four-ingredient formula — CoQ10 (Coenzyme Q10), Milk Thistle, Licorice Root, and Tulsi (Holy Basil) — works through distinct and complementary mechanisms to protect liver cells from damage, reduce hepatic inflammation, prevent fibrosis, support liver detoxification pathways, and restore healthy lipid metabolism in the liver.

Recommended by veterinarians for a broad range of hepatic conditions, HepNSure is safe for long-term supplementation and available in an easy-to-administer palatable tablet format.

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The Science of HepNSure’s Four-Ingredient Formula

CoQ10 (Coenzyme Q10) — Cellular Energy & Mitochondrial Protection

CoQ10 is a naturally occurring compound found in every cell of the body, with particularly high concentrations in the liver — one of the most metabolically active organs in the body. CoQ10’s primary role is in the mitochondrial electron transport chain — the process by which cells generate ATP (cellular energy). Without adequate CoQ10, mitochondrial function declines and cells — including hepatocytes (liver cells) — cannot produce the energy required for normal function, repair, and detoxification activity.

In the context of liver disease, CoQ10 is particularly significant because hepatic mitochondrial dysfunction is a key driver of liver cell death and disease progression in conditions like hepatitis, fatty liver disease, and cirrhosis. By supporting mitochondrial energy production, CoQ10 helps maintain hepatocyte viability and function. Its potent antioxidant properties also directly neutralise the reactive oxygen species (free radicals) that liver cells generate during detoxification — reducing oxidative damage to the liver tissue that would otherwise accumulate over time.

CoQ10’s inclusion in HepNSure is what makes this supplement genuinely different from basic Milk Thistle-only liver products — it addresses the energy and mitochondrial dimension of liver health that herbal ingredients alone cannot fully cover.

Milk Thistle (Silymarin) — The Gold Standard Hepatoprotective Herb

Milk Thistle — specifically its active compound silymarin — is the most extensively researched and clinically supported hepatoprotective herb in both human and veterinary medicine. Its mechanisms of action in the liver are well-established and multi-dimensional:

Silymarin protects hepatocyte cell membranes from toxin penetration by modifying their surface structure to prevent toxic compounds from binding and entering liver cells. This is particularly relevant for pets exposed to hepatotoxic medications, environmental toxins, or heavy metal accumulation.

Silymarin actively stimulates hepatocyte regeneration by promoting the synthesis of ribosomal RNA (rRNA) in liver cells — effectively accelerating the growth of new, healthy liver cells to replace damaged ones.

Silymarin reduces hepatic inflammation through inhibition of inflammatory mediator production — critical in conditions like hepatitis and cholangiohepatitis where inflammatory damage to liver tissue is the primary driver of disease progression.

Silymarin also has antifibrotic properties — it inhibits the activation of hepatic stellate cells that produce collagen in the liver, thereby helping prevent the progressive scarring of liver tissue that leads to fibrosis and cirrhosis.

Licorice Root (Glycyrrhiza) — Anti-Inflammatory & Antifibrotic Liver Support

Licorice root contains glycyrrhizin and glycyrrhizinic acid — compounds with documented hepatoprotective, anti-inflammatory, and antifibrotic activity. In liver health specifically, licorice has demonstrated the ability to inhibit liver cell apoptosis (programmed cell death) under inflammatory and toxic conditions, reduce the production of pro-inflammatory cytokines that drive hepatic inflammation, and inhibit the fibrotic process that converts healthy liver tissue into non-functional scar tissue.

Licorice also has a synergistic relationship with Milk Thistle — the two herbs together produce greater hepatoprotective activity than either ingredient alone — making their combination in HepNSure a deliberate formulation decision rather than simply a list of individually useful ingredients.

Ocimum sanctum — Tulsi (Holy Basil) — Antioxidant, Antimicrobial & Hepatoprotective

Tulsi completes HepNSure’s formula with its broad antioxidant, anti-inflammatory, and hepatoprotective properties. Tulsi’s active compounds — including eugenol, rosmarinic acid, and ursolic acid — provide antioxidant protection to liver tissue, antimicrobial activity that helps protect against the secondary infections to which pets with compromised liver function are particularly vulnerable, and adaptogenic properties that help manage the systemic physiological stress that accompanies liver disease.

Tulsi also has documented hepatoprotective activity in its own right — it has been shown to reduce the elevation of liver enzymes (ALT, AST, ALP) in hepatotoxic conditions, protect against toxin-induced liver damage, and support normal bile flow and hepatic lipid metabolism.

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Conditions Where HepNSure Is Indicated

HepNSure is specifically recommended for dogs and cats with:

Acute & Chronic Hepatitis — inflammation of the liver driven by infection, immune-mediated mechanisms, or idiopathic causes — the most common liver condition in dogs and cats

Hepatic Fibrosis & Cirrhosis — progressive scarring of liver tissue that impairs hepatic function — HepNSure’s antifibrotic ingredients help slow progression and support residual liver function

Post-Drug Therapy Liver Support — many medications — including NSAIDs, antibiotics, anticonvulsants, and corticosteroids — place significant metabolic burden on the liver. HepNSure provides hepatoprotective support during and after extended medication courses

Fatty Liver Disease / Hepatic Lipidosis — abnormal accumulation of fat within liver cells that impairs function — particularly common in cats; CoQ10 and the herbal antioxidants support hepatic lipid metabolism normalisation

Cholangiohepatitis — simultaneous inflammation of the bile ducts and liver, particularly prevalent in cats

Toxin-Induced Liver Damage — environmental toxins, dietary indiscretions involving toxic substances, or occupational/environmental chemical exposures that cause hepatic injury

Inappetence & Debility Associated with Liver Disease — loss of appetite and generalised weakness that often accompanies hepatic conditions

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Key Benefits

• Protects liver cells from toxin-induced damage — Milk Thistle’s silymarin actively prevents toxic compounds from penetrating and damaging hepatocyte cell membranes
• Supports mitochondrial energy in liver cells — CoQ10 addresses the cellular energy deficit that drives hepatocyte death in liver disease
• Reduces hepatic inflammation — both Licorice and Tulsi reduce the production of inflammatory mediators driving hepatitis and cholangiohepatitis
• Antifibrotic action — Milk Thistle and Licorice together inhibit the stellate cell activation and collagen production that converts healthy liver tissue to scar tissue
• Stimulates liver cell regeneration — silymarin promotes the growth of new healthy hepatocytes to replace damaged ones
• Enhances liver detoxification — supports the liver’s Phase I and Phase II detoxification pathways, improving the efficiency with which the liver processes and eliminates metabolic waste and toxic compounds
• Safe for long-term supplementation — the all-natural formula is appropriate for extended daily use, making it suitable for management of chronic hepatic conditions

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Ingredients

Active Ingredients: CoQ10 (Coenzyme Q10) — mitochondrial energy support, antioxidant Silybum marianum — Milk Thistle (Silymarin) — hepatoprotective, antifibrotic, liver cell regeneration Glycyrrhiza glabra — Licorice Root — anti-inflammatory, antifibrotic, hepatoprotective Ocimum sanctum — Tulsi / Holy Basil — antioxidant, antimicrobial, hepatoprotective

Pack Size: 24 tablets

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Dosage Guide

Administer once daily. Tablets may be given directly to the pet or mixed into food.

Dogs & Puppies: Under 12 kg (Puppies) → ½ tablet per day 13–24 kg → 1 tablet per day 25–35 kg → 1–1½ tablets per day Above 35 kg (Large Adult Dogs) → maximum 2 tablets per day

Cats: Under 6 kg (Kittens) → ½ tablet per day Above 6 kg → 1 tablet per day

Always follow the dosage guidance of your veterinarian, particularly for pets with active liver disease who may require adjusted dosing based on clinical assessment.

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Who Is This For?

• Dogs and cats diagnosed with any form of liver disease — hepatitis, fibrosis, cirrhosis, fatty liver, cholangiohepatitis — where ongoing hepatoprotective support is part of the management plan
• Pets on extended courses of hepatotoxic medications — NSAIDs, anticonvulsants, corticosteroids, certain antibiotics — where liver protection during treatment is clinically indicated
• Senior pets experiencing age-related hepatic function decline who benefit from daily antioxidant and mitochondrial support for the liver
• Pets recovering from toxin exposure or hepatic injury where liver cell regeneration and inflammation management are priorities
• Pet parents who want a scientifically formulated, multi-ingredient liver supplement that goes beyond basic Milk Thistle alone

Important: This product is for animal use only. Liver disease in pets requires veterinary diagnosis and management. HepNSure is a supplement — not a replacement for veterinary treatment. Always consult your veterinarian before beginning supplementation, particularly if your pet is on other liver medications. Not for human consumption.